Waste has significant impact on ecosystem and pose threats to human health and wellbeing. Waste also threatens the integrity of habitats that are essential to biological diversity. The challenge is to develop responses to waste issues that can improve the quality of human life and biodiversity. 
LEAD Nepal aims to reduce reuse and recycle (3R) waste, with minimum waste going to landfill. LEAD Nepal jointly with other NGO’s and PPAP conducted research and organized workshops on waste management in and outside Kathmandu valley.
In 2009, LEAD Nepal with partnership with Solid Waste Management Recovery Center, Ministry of Local Development Nepal, conducted a research on Zero Waste Management Project for Kathmandu and Lalitpur District in Nepal. LEAD Nepal based on its research extended its service to prepare the technical proposal for Integrated Solid Waste Management of Kathmandu Valley with BOT model on zero waste concepts.
Disaster Waste Management
In 2008, LEAD Nepal with support from Nepal Eco-tech Pvt. Ltd. did a research on Earthquake Hazard Management. Further, in response of the earth quack on 25 April 2015, Ministry of Federal Affairs and Local Development (MoFALD) jointly with Lead Nepal support by UNEP conducted a research on Disaster Waste and have prepared the Disaster Waste Management Policy, Strategy an Action Plan for Nepal. LEAD Nepal has conducted several workshops locally and have travelled internatinally representing Nepal on issues related to Disaster Waste Management
Nepal jointly with Karuna Shechen, has assessed the situation on 12 earth quack affected districts and is working on disaster waste management in the field level.
 M.K.C. Sridhar, Joe Baker & N.O. Adedipe, Waste Management, Processing, and Detoxification, Chapter 10, page 316